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NSC 23766
- Parent CAS: 733767-34-5
- Soluble in water and DMSO
- MF: C24H35N7.3HCl
- MW: 530.96
Description
A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM) without affecting the closely related GTPases, Cdc42, and RhoA activation.
A useful tool for studying the Rac-mediated cellular functions and for modulating pathological conditions in which Rac-deregulation may play a role.
More Information
| Parent CAS No. | 733767-34-5 |
|---|---|
| Chemical Name | N*6*-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride |
| SMILES | C1=CC(NC2N=C(NC(CCCN(CC)CC)C)N=C(C)C=2)=CC2=C(N)C=C(C)N=C12.Cl.Cl.Cl |
| MFCD | MFCD08703096 |
| InChi | InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H |
| InChiKey | CPUHORIUXPQCHW-UHFFFAOYSA-N |
| CID | 16759159 |
| Short Description | Rac1-GEF inhibitor |
References
- M Vallon et al. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Exp. Cell Res. 2010, 316 412-421.
- EE Bosco et al. Rac1 GTPase: A “Rac” of all trades. Cell Mol. Life Sci. 2009, 66 370-374.
- J Wang et al. Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth. Biochem Biophys Res Commun 2009, 386 769-774.
- Hable W.E. Et al. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. PLANTA 2008, 227(5), 991-1000.
- JA Cancelas et al. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med 2005, 11(8), 886-891.
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