GDC 0879

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1459

CAS [905281-76-7]

MF C19H18N4O2
MW 334.37

Purity: 99%
Soluble in DMSO

GDC 0879

Description

Selective inhibitor of protein kinase, targeting B-Raf (V600E)

KP Hoeflich et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/MAPK pathway suppression. Cancer Res. 2009, 69(7), 3042-3051.

H Wong et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor. J. Pharmacol. Exp. Ther. 2009, 329(1), 360-367.

B-Raf protein kinase inhibitor

Chemical name

5-[1-(2-Hydroxy-ethyl)-3-pyridin-4-yl-1H-pyrazol-4-yl]-indan-1-one oxime

Parent CAS No.

[905281-76-7]

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2 mg	€70.00	In Stock
5 mg	€105.00	In Stock
25 mg	€365.00	In Stock

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2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

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