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β-Funaltrexamine hydrochloride
- β-FNA hydrochloride
- Parent CAS: 72782-05-9
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C25H30N2O6.HCl
- MW: 490.98
Description
β-Funaltrexamine hydrochloride (β-FNA hydrochloride) is a selective and irreversible μ-opioid receptor (MOR) antagonist. β-FNA binds covalently to the μ-opioid receptor, producing long-lasting inhibition of receptor activity and making it a valuable pharmacological tool for studying opioid receptor function.
Due to its irreversible mode of action, β-FNA is widely used to investigate μ-opioid receptor-mediated signaling, analgesia, tolerance, dependence, and receptor regulation in both in vitro and in vivo models.
Key Features
- Selective irreversible μ-opioid receptor antagonist
- Covalently binds to the μ-opioid receptor
- Produces long-lasting receptor blockade
- Widely used in opioid pharmacology research
- Useful tool for studying opioid receptor signaling and regulation
Applications
- μ-Opioid receptor (MOR) research
- Opioid signaling pathway studies
- Analgesia and pain research
- Opioid tolerance and dependence studies
- Receptor pharmacology and neurobiology research
More Information
| Parent CAS No. | 72782-05-9 |
|---|---|
| Chemical Name | (2E)-4-[[(5a,6b)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-Butenoic acid methyl ester, hydrochloride (1:1) |
| SMILES | [C@@]123CCN(CC4CC4)[C@@H]4CC5=CC=C(O)C(O[C@@]1([H])[C@@H](CC[C@]24O)NC(=O)/C(/[H])=C([H])/C(=O)OC)=C35.Cl |&1:0,8,17,19,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H30N2O6.ClH/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14;/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29);1H/b7-6+;/t16-,18-,23+,24+,25-;/m1./s1 |
| InChiKey | BIPHUOBUKMPSQR-NQGXHZAGSA-N |
| CID | 44522395 |
| Short Description | Mu-opioid antagonist |
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