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ADL 5859
- Parent CAS: 850305-06-5
- Soluble in DMSO
- MF: C24H29ClN2O3
- MW: 428.95
Description
ADL 5859 is a highly potent and selective δ-opioid receptor agonist with a Ki value of 0.84 nM and an ED50 value of 20 nM in reported assays.
δ-Opioid receptor signaling modulates nociception, mood and GPCR-mediated analgesic pathways. ADL 5859 is useful for studying δ-opioid receptor activation and subtype-selective opioid pharmacology.
Key Features
- Potent δ-opioid receptor agonist
- Ki: 0.84 nM
- Reported ED50: 20 nM
- Selective tool for delta opioid receptor signaling
Applications
- δ-opioid receptor pharmacology
- Pain and analgesia pathway studies
- GPCR agonist assay development
- Opioid receptor subtype selectivity profiling
More Information
| Parent CAS No. | 850305-06-5 |
|---|---|
| Chemical Name | N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride |
| SMILES | C1C(O)=C2C(C3C=CC(C(N(CC)CC)=O)=CC=3)=CC3(CCNCC3)OC2=CC=1.Cl |
| MFCD | MFCD17215194 |
| InChi | InChI=1S/C24H28N2O3.ClH/c1-3-26(4-2)23(28)18-10-8-17(9-11-18)19-16-24(12-14-25-15-13-24)29-21-7-5-6-20(27)22(19)21;/h5-11,16,25,27H,3-4,12-15H2,1-2H3;1H |
| InChiKey | ZFNLSWREIULTDO-UHFFFAOYSA-N |
| CID | 46931003 |
| Short Description | δ-opioid agonist |
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