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Nalmefene hydrochloride
- Parent CAS: 55096-26-9
- Soluble in water and DMSO
- MF: C21H25NO3.HCl
- MW: 375.89
Description
Nalmefene hydrochloride is an opioid receptor modulator that acts primarily as an antagonist at μ- and δ-opioid receptors with partial agonist activity at κ-opioid receptors.
Opioid receptor signaling influences reward, analgesia, stress responses and compulsive intake behaviors. Nalmefene is relevant for research on alcohol-use pharmacology, opioid receptor subtype function and modulation of mesolimbic reward pathways.
Key Features
- Opioid receptor antagonist/modulator
- Antagonist activity at μ- and δ-opioid receptors
- Partial agonist activity at κ-opioid receptors
- Relevant to alcohol-dependence and reward-circuit research
Applications
- Opioid receptor pharmacology
- Addiction and alcohol intake models
- Reward pathway studies
- Kappa-opioid receptor signaling assays
More Information
| Parent CAS No. | 55096-26-9 |
|---|---|
| Chemical Name | 17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-diol |
| MFCD | MFCD00133650 |
| Short Description | Opioid antagonist |
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