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Naloxonazine dihydrochloride
- NSC 612113
- Parent CAS: 82824-01-9
- Optical Purity: Optically pure
- Soluble in water
- MF: C38H42N4O6.2HCl
- MW: 723.69
Description
Naloxonazine dihydrochloride is a potent, irreversible mu (μ)-opioid receptor (MOR) antagonist with selectivity for the μ1 opioid receptor subtype in pharmacological studies.
μ opioid receptor subtypes are involved in opioid analgesia, tolerance, dependence and respiratory effects. Naloxonazine is used to differentiate μ1-mediated responses from other opioid receptor signaling components.
Key Features
- Selective μ1 opioid receptor antagonist profile
- Blocks μ opioid receptor-mediated responses
- Useful for opioid receptor subtype discrimination
- Relevant to analgesia, tolerance and dependence pathway research
Applications
- Opioid receptor pharmacology
- μ1 receptor subtype studies
- Analgesia and opioid response models
- Receptor selectivity and antagonist assay development
More Information
| Parent CAS No. | 82824-01-9 |
|---|---|
| Chemical Name | 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, 2-[(5a)-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-ylidene]hydrazone-morphinan-6-one dihydrochloride |
| SMILES | [C@@]123CCN(CC=C)[C@@H]4CC5C=CC(O)=C(O[C@H]1/C(/CC[C@]24O)=N/N=C1CC[C@@]2(O)[C@H]4CC6C=CC(O)=C7C=6[C@@]2(CCN4CC=C)[C@H]1O7)C3=5.Cl.Cl |&1:0,7,16,20,27,29,38,45,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C38H42N4O6.2ClH/c1-3-15-41-17-13-35-29-21-5-7-25(43)31(29)47-33(35)23(9-11-37(35,45)27(41)19-21)39-40-24-10-12-38(46)28-20-22-6-8-26(44)32-30(22)36(38,34(24)48-32)14-18-42(28)16-4-2;;/h3-8,27-28,33-34,43-46H,1-2,9-20H2;2*1H/b39-23+,40-24+;;/t27-,28-,33+,34+,35+,36+,37-,38-;;/m1../s1 |
| InChiKey | VIAIHLLKDJKEKM-DCBBKWFGSA-N |
| CID | 16219724 |
| Short Description | Opioid antagonist |
References
- D Paul et al. Differential blockade by naloxonazine of two mu opiate actions: analgesia and inhibition of gastrointestinal transit. Eur J Pharmacol. 1988 May 10;149(3):403-4.
- CC Chien et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212(1):61-5.
- EF Hahn et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31(12-13):1385-8.
- G De Muylder et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10(12):e0005234.
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