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XL 413 hydrochloride

 - BMS 863233 hydrochloride
Axon 2268
  • Parent CAS:  1169558-38-6
Purity:  99%
  • Soluble in water and DMSO
  • MF:  C14H12ClN3O2.HCl
  • MW:  326.18

Description

Potent, selective and orally bioavailable CDC7 inhibitor (IC50 value of 3.4 nM) that shows >60-fold selectivity against CK2, >10-fold selectivity against PIM1, and >300-fold selectivity against a panel of over 100 protein kinases. XL 413 induces tumor cell apoptosis and inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.Further development of XL 413 was terminated due to an unfavorable pharmacological profile observed in phase 1 clinical evaluation.

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1169558-38-6
Chemical Name (S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
MFCD N.A.
Short Description CDC7 inhibitor

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