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5 mg

$121.00

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25 mg

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2 x 25 mg $836.00 $682.00 In stock

GSK 1838705A

Name: GSK 1838705A
SKU: 2267

- GSK 1838705

Axon 2267

CAS: 1116235-97-2

Purity: 99%

Soluble in DMSO

MF: C27H29FN8O3
MW: 532.57

Description

Potent and selective insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor with additional affinity for anaplastic lymphoma kinase (ALK) with IC50 values of 2.0 nM, 1.6 nM, and 0.6 nM, for IGF1R, IR, and ALK respectively, and >800-fold selectivity over related kinases, including RSK1, JNK3, and B-Raf V600EGSK 1838705A inhibits the proliferation of cancer cell lines, comprises the growth of human tumor xenografts in vivo, and causes complete regression of ALK-dependent tumors in vivo at well-tolerated doses.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

IGF1R

Parent CAS No.	1116235-97-2
Chemical Name	2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide
SMILES	C1(OC)C(NC2N=C(NC3C(C(=O)NC)=C(F)C=CC=3)C3C=CNC=3N=2)=CC2N(C(=O)CN(C)C)CCC=2C=1
MFCD	MFCD19443644
InChi	InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)
InChiKey	HZTYDQRUAWIZRE-UHFFFAOYSA-N
CID	25182616
Short Description	IGF1R/IR inhibitor

GSK 1838705A IGF1R/IR kinase inhibitor Axon Medchem Axon 2267 GSK1838705A GSK1838705 GSK 1838705 Insulin Growth Factor ALK IGF1R IR human cancer Supplier Vendor

References

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GSK 1838705A

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