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FQI 1

Axon 2157
CAS:  599151-35-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C18H17NO4
  • MW:  311.33

Description

Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible. FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model.

More Information

Parent CAS No. 599151-35-6
Chemical Name 8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
SMILES N1C2=C(C=C3OCOC3=C2)C(C2=CC=CC=C2OCC)CC1=O
MFCD N.A.
InChi InChI=1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
InChiKey YKSYGLXHLSPWLB-UHFFFAOYSA-N
CID 656346
Short Description LSF inhibitor

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