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Gö 6983
- GO 6983 - Goe 6983
- Soluble in DMSO
- MF: C26H26N4O3
- MW: 442.51
Description
Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). Gö6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.
*Promotion: Gö 6983 is also part of Inhibitor Set(s):
| Naive Stem Cell NHSM inhibitor Set (Axon 5010) |
More Information
| Parent CAS No. | 133053-19-7 |
|---|---|
| Chemical Name | 3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| SMILES | N1C(=O)C(C2C3=C(NC=2)C=CC=C3)=C(C2C3=C(N(CCCN(C)C)C=2)C=CC(OC)=C3)C1=O |
| MFCD | MFCD04040031 |
| InChi | InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32) |
| InChiKey | LLJJDLHGZUOMQP-UHFFFAOYSA-N |
| CID | 3499 |
| Short Description | PKC inhibitor |
References
- M. Gschwendt et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.
- I. Iankov et al. The effect of chemical blockade of PKC with Gö6976 and Gö6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells. Leuk Res. 2002 Apr;26(4):363-8.
- K.C. Hwang et al. Chemicals that modulate stem cell differentiation. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7467-71.
- O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6.
- L.H. Young et al. Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev. 2005 Fall;23(3):255-72.
- List of publications using Gö 6983 (Axon 2466) purchased from Axon Medchem
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