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GW 311616A
- GW 311616 hydrochloride
- Parent CAS: 198062-54-3
- Optical Purity: >99% e.e.
- Soluble in water and DMSO
- MF: C19H31N3O4S.HCl
- MW: 433.99
Description
More Information
| Parent CAS No. | 198062-54-3 |
|---|---|
| Chemical Name | (3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride |
| SMILES | N1(S(C)(=O)=O)C(=O)[C@@H](C(C)C)[C@@H]2N(C(=O)/C=C/CN3CCCCC3)CC[C@@H]12.Cl |&1:7,11,26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1 |
| InChiKey | UFCZUKYPBPXODT-OFTZGUNKSA-N |
| CID | 9889108 |
| Short Description | HNE inhibitor |
References
- S.J. Macdonald et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.
- J.W. Cooke et al. A novel and selective approach to enantiomerically pure bicyclic-trans-lactams via a titanium enolate of a thiopyridyl ester. J Org Chem. 2001 Jan 12;66(1):334-6.
- S.J.F. Macdonald et al. A flexible, practical, and stereoselective synthesis of enantiomerically pure trans-5-oxohexahydropyrrolo[3,2-b]pyrroles (pyrrolidine-trans-lactams), a new class of serine protease inhibitors....J.O.C. 1999 June 17, 64(14), 5166-5175.
- V. Papayannopoulos et al. Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy. PLoS One. 2011;6(12):e28526.
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