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WS-383
- DCN1-UBC12 interaction inhibitor E31
- Soluble in DMSO
- MF: C18H20ClN9S2
- MW: 461.99
Description
WS-383 effectively blocks interaction between DCN1 and UBC12 (IC50 value of 11 nM), causes selective Cul3/1 neddylation inhibition over other cullins, and induces accumulation of p21, p27, and NRF2.
More Information
| Parent CAS No. | 2247543-65-1 |
|---|---|
| Chemical Name | 2-(5-(2-(4-Chlorobenzylthio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylthio)-1H-tetrazol-1-yl)-N,N-dimethylethanamine |
| SMILES | C1=C(SC2=NN=NN2CCN(C)C)N2N=C(SCC3C=CC(Cl)=CC=3)N=C2N=C1C |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20ClN9S2/c1-12-10-15(30-18-22-24-25-27(18)9-8-26(2)3)28-16(20-12)21-17(23-28)29-11-13-4-6-14(19)7-5-13/h4-7,10H,8-9,11H2,1-3H3 |
| InChiKey | MGESDQAAIJOGJA-UHFFFAOYSA-N |
| CID | 138319704 |
| Short Description | DCN1-UBC12 inhibitor |
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