TG100-115
- Soluble in DMSO
- MF: C18H14N6O2
- MW: 346.34
Description
A PI3K P110 ץ/δ isoform-selective inhibitor with IC50 values (nM) of 1300, 1200, 83 and 235 for p110α, p110β, P110 ץ, and P110δ isoforms, respectively.
More Information
| Parent CAS No. | 677297-51-7 |
|---|---|
| Chemical Name | 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(C2C=CC=C(O)C=2)N=C2C(N)=NC(N)=NC2=NC=1C1C=C(O)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) |
| InChiKey | UJIAQDJKSXQLIT-UHFFFAOYSA-N |
| CID | 10427712 |
| Short Description | PI3K P110 ץ/δ inhibitor |
References
- MS Palanki et al. Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J Med Chem. 2007 Sep 6;50(18):4279-94.
- J Doukas et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
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