GS-9901
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H17ClFN9O
- MW: 477.88
Description
GS-9901 is an orally active, potent and isoform-selective inhibitor of PI3Kδ (PI3Kδ IC50 = 1.0 nM, HWB δ EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.), and a potential immunomodulating agent. It is highly selective against other isoforms: p110α (750 nM), p110β (100 nM) and P110γ (190 nM).
More Information
| Parent CAS No. | 1640247-87-5 |
|---|---|
| Chemical Name | (S)-2,4-diamino-6-((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methylamino)pyrimidine-5-carbonitrile |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C(Cl)=C2C(=O)N(C3C=NC=CC=3)C([C@@H](NC3N=C(N)N=C(N)C=3C#N)C3CC3)=NC2=C(F)C=1 |&1:14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H17ClFN9O/c23-13-5-6-14(24)17-15(13)21(34)33(11-2-1-7-28-9-11)20(30-17)16(10-3-4-10)29-19-12(8-25)18(26)31-22(27)32-19/h1-2,5-7,9-10,16H,3-4H2,(H5,26,27,29,31,32)/t16-/m0/s1 |
| InChiKey | XDSXYMOZKDUASY-INIZCTEOSA-N |
| CID | 86763204 |
| Short Description | PI3Kδ inhibitor |
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