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ER-819762
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C30H39N3O3
- MW: 489.65
Description
ER-819762 is a selective and orally available antagonist of the prostaglandin E2 receptor EP4 (PTGER4) with an IC50 value of 70 nM. It blocks PGE2-driven EP4 signaling, a pathway involved in inflammatory-cell activation, vascular responses and pain sensitization.
ER-819762 has demonstrated activity in collagen-induced and glucose-6-phosphate-isomerase-induced arthritis models and in a rat model of chronic inflammatory pain. It is useful for studying EP4-dependent inflammation, immune regulation and nociceptive signaling.
Key Features
- Selective EP4 receptor antagonist
- IC50: 70 nM
- Orally available
- Bioactive in arthritis and inflammatory-pain models
Applications
- EP4 and PTGER4 receptor research
- Prostaglandin E2 signaling studies
- Arthritis models
- Inflammatory pain research
- Immune and vascular response assays
More Information
| Parent CAS No. | 1155773-15-1 |
|---|---|
| Chemical Name | (S,Z)-1'-(3,5-Dimethylbenzyl)-2-ethyl-7,9-dimethoxy-10-methyl-5,10-dihydrospiro[benzo[e]imidazo[1,5-a]azepine-1,4'-piperidin]-3(2H)-one |
| SMILES | C1C2(C3=C[C@H](C)C4C(OC)=CC(OC)=CC=4CN3C(=O)N2CC)CCN(CC2C=C(C)C=C(C)C=2)C1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H39N3O3/c1-7-33-29(34)32-19-24-16-25(35-5)17-26(36-6)28(24)22(4)15-27(32)30(33)8-10-31(11-9-30)18-23-13-20(2)12-21(3)14-23/h12-17,22H,7-11,18-19H2,1-6H3/t22-/m0/s1 |
| InChiKey | ANKFBAJRCGOKJJ-QFIPXVFZSA-N |
| CID | 42596951 |
| Short Description | PGE receptor 2 (EP4) antagonist |
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