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Grapiprant
- CJ-023,423
Axon 3787
CAS:
415903-37-6
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C26H29N5O3S
- MW: 491.61
Description
Grapiprant is a potent, selective, competitive and orally bioavailable prostaglandin EP4 receptor antagonist with Ki values of 13 nM and 20 nM for human and rat EP(4) receptors, respectively. Grapiprant produces antihyperalgesic effects in animal models of inflammatory pain.
More Information
| Parent CAS No. | 415903-37-6 |
|---|---|
| Chemical Name | N-(4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethylcarbamoyl)-4-methylbenzenesulfonamide |
| SMILES | N1C(C)=C2N=C(CC)N(C3C=CC(CCNC(=O)NS(=O)(=O)C4C=CC(C)=CC=4)=CC=3)C2=CC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32) |
| InChiKey | HZVLFTCYCLXTGV-UHFFFAOYSA-N |
| CID | 11677589 |
| Short Description | EP4 antagonist |
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