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S 5751
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C25H31NO4S
- MW: 441.58
Description
S 5751 is a potent, selective and orally active prostaglandin D2 DP receptor antagonist with reported Ki values of 1.6 nM for human DP and 24.2 nM for TP receptors.
PGD2-DP receptor signaling contributes to allergic inflammation, airway responses and immune-cell recruitment. S 5751 is useful for studying prostanoid receptor selectivity and the role of DP signaling in respiratory and allergic disease models.
Key Features
- Potent DP prostaglandin receptor antagonist
- Reported Ki: 1.6 nM for human DP receptor
- Selectivity over thromboxane TP receptor reported
- Useful for PGD2-driven allergic inflammation studies
Applications
- Prostaglandin D2 receptor pharmacology
- Asthma and airway inflammation models
- Allergy and immune-cell recruitment research
- Prostanoid receptor selectivity assays
More Information
| Parent CAS No. | 209268-36-0 |
|---|---|
| Chemical Name | (Z)-7-((1R,2R,3S,5S)-2-(5-hydroxybenzo[b]thiophene-3-carboxamido)-6,6-dimethylbicyclo[3.1.1]heptan-3-yl)hept-5-enoic acid |
| SMILES | N([C@@H]1[C@H](C[C@H]2C[C@@H]1C2(C)C)C/C=CCCCC(=O)O)C(C1=CSC2C=CC(O)=CC1=2)=O |&1:1,2,4,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H31NO4S/c1-25(2)16-11-15(7-5-3-4-6-8-22(28)29)23(20(25)12-16)26-24(30)19-14-31-21-10-9-17(27)13-18(19)21/h3,5,9-10,13-16,20,23,27H,4,6-8,11-12H2,1-2H3,(H,26,30)(H,28,29)/b5-3-/t15-,16-,20-,23+/m0/s1 |
| InChiKey | ZXBHFWFKSIYJEK-MFJOXFORSA-N |
| CID | 9867949 |
| Short Description | PGD2 antagonist |
References
- A Arimura et al. Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751. J. Pharmacol. Exp. Ther. 2001, 298(2), 411-419.
- S Mitsumori et al. Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists... J. Med. Chem. 2003, 46(12), 2446-55.
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