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ONO 8711 dicyclohexyl amine salt
- Soluble in DMSO
- MF: C22H30ClNO4S.C12H23N
- MW: 621.31
Description
ONO 8711 dicyclohexyl amine salt is a selective prostaglandin E2 EP1 receptor antagonist used to block EP1-mediated PGE2 signaling.
EP1 receptor activation contributes to prostaglandin-driven inflammation, pain signaling, smooth-muscle responses and tumor-promoting pathways. ONO 8711 is useful for dissecting EP1-dependent biology in inflammatory and chemoprevention research models.
Key Features
- Selective antagonist of the PGE2 EP1 receptor
- Blocks EP1-mediated prostaglandin signaling
- Relevant to inflammation and pain pathway research
- Useful in models of prostaglandin-associated tumor promotion
Applications
- EP1 receptor pharmacology
- Prostaglandin E2 pathway studies
- Inflammation and nociception research
- Cancer chemoprevention model systems
More Information
| Parent CAS No. | 216158-34-8 |
|---|---|
| Chemical Name | (Z)-6-{(2R,3S)-3-[(4-Chloro-2-methyl-benzenesulfonylamino)-methyl]-bicyclo[2.2.2]oct-2-yl}-hex-5-enoic acid dicyclohexyl-amine salt |
| MFCD | MFCD11840656 |
| Short Description | EP1 antagonist |
References
- T Kawamori et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on breast cancer development. Carcinogenesis. 2001, 22(12), 2001-2004.
- H Makita et al. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis 2007, 28(3), 677-684.
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