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ICI 192605

Axon 1210
CAS:  117621-64-4
  • Optical Purity:  Optically pure
  • Soluble in DMSO and EtOH
  • MF:  C22H23ClO5
  • MW:  402.87

Description

ICI 192605 is a potent, selective and orally active thromboxane A2 receptor (TP) antagonist.

The thromboxane TP receptor mediates platelet activation, vasoconstriction, bronchoconstriction and prostanoid-driven inflammatory responses. ICI 192605 is used to define TP receptor contributions in cardiovascular, pulmonary and platelet pharmacology.

Key Features

  • Selective thromboxane A2/TP receptor antagonist
  • Blocks prostanoid receptor-mediated responses
  • Orally active in pharmacological models
  • Relevant to platelet, vascular and airway signaling studies

Applications

  • TP receptor antagonist assays
  • Platelet activation and aggregation research
  • Vascular tone and vasoconstriction models
  • Prostanoid signaling pathway studies

More Information

Parent CAS No. 117621-64-4
Chemical Name (Z)-6-[rel-(2S,4S,5R)-2-(2-Chloro-phenyl)-4-(2-hydroxy-phenyl)-[1,3]dioxan-5-yl]-hex-4-enoic acid (relative stereochemistry)
SMILES O1C[C@@H](C/C=CCCC(=O)O)[C@@H](C2C=CC=CC=2O)O[C@H]1C1C=CC=CC=1Cl |&1:2,11,20,r|
MFCD N.A.
InChi InChI=1S/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1-/t15-,21+,22+/m1/s1
InChiKey WHUIENZXNGAHQI-GKZDNZBASA-N
CID 6604763
Short Description TP antagonist

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