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Abiraterone
- CB 7598
- Optical Purity: Optically pure
- Moderately soluble in DMSO
- MF: C24H31NO
- MW: 349.51
Description
Inhibitor of the steroidal enzyme 17 α-hydroxylase/C17,20 lyase (CYP17A1); a drug used in castration-resistant prostate cancer (CRPC); active component of its formulated prodrug abiraterone acetate (Axon 1874), which is also available
More Information
| Parent CAS No. | 154229-19-3 |
|---|---|
| Chemical Name | (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| SMILES | [C@]12(C)CC[C@]3([H])[C@@]4(C)CC[C@H](O)CC4=CC[C@@]3([H])[C@]1([H])CC=C2C1C=NC=CC=1 |&1:0,4,6,10,16,18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1 |
| InChiKey | GZOSMCIZMLWJML-VJLLXTKPSA-N |
| CID | 132971 |
| Short Description | CYP17A1 inhibitor |
References
- G Attard et al. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005, 96 (9), 1241–1246.
- JE Ang et al. CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Br. J. Cancer 2009, 100(5), 671–675.
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