UPF 1069

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2369

CAS [1048371-03-4]

MF C17H13NO3
MW 279.29

Purity: 99%
Soluble in DMSO

UPF 1069

Description

PARP-2 inhibitor with >26 fold selectivity over PARP1 (IC50 values 8.0 µM and 0.3 µM for PARP1 and PARP2, respectively) that exacerbates oxygen-glucose deprivation (OGD) injury in the hippocampus, but significantly attenuates OGD damage in mixed cortical cell cultures at concentrations high enough to inhibit both PARP1 and PARP2. UPF 1069 is a valuable tool to explore the function of PARP-2 in biological systems and to examine the different roles of PARP isoenzymes in the mechanisms of cell death and survival.

F. Moroni et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br. J. Pharmacol. 2009, 157, 854-862.

R. Pellicciari et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008, 3, 914-923.

T. Haikarainen et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med. Chem. Lett. 2013, 5, 18-22.

Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Epigenetics DNA-damage Response EC 2.4.2.30 PARP

PARP-2 inhibitor with >26 fold selectivity over PARP1

Chemical name

5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one

Parent CAS No.

[1048371-03-4]

Order

Size	Unit Price	Stock
10 mg	€75.00	In Stock
50 mg	€225.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1268	DR 2313	PARP inhibitor		€90.00
1370	NU 1025	PARP inhibitor		€80.00
1464	Olaparib	PARP inhibitor		€50.00
1496	3-Aminobenzamide	Competitive small molecule inhibitor of PARP		€40.00
1529	AG 014699	PARP1 inhibitor		€60.00
1566	Iniparib	PARP inhibitor		€60.00
1593	Veliparib	PARP inhibitor		€40.00
2001	KU-0058948 hydrochloride	Potent and specific PARP1 inhibitor		€135.00
2241	AZD2461	PARP inhibitor with poor P-glycoprotein substrate qualities		€95.00
2502	Talazoparib	Potent, selective, and orally available PARP1/2 inhibitor		€90.00
2759	ME0328	PARP3/ARTD3 inhibitor		€95.00
2888	Veliparib dihydrochloride	PARP inhibitor		€95.00
2928	Niraparib	Potent, selective, and orally available PARP1/2 inhibitor		€90.00
2885	GeA-69	Selective allosteric and cell-active PARP14 MD2 inhibitor		€95.00
3113	Rucaparib camsylate	PARP1 inhibitor		€90.00
3398	E7449 mesylate	Potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and TNKS1/2		€110.00
4179	KU-0058948	Potent and specific PARP1 inhibitor	Recently added	€135.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

UPF 1069

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

UPF 1069

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us