γ-Secretase Inhibitor DBZ - Deshydroxy LY411575 | YO-01027

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1488

CAS [209984-56-5]

MF C26H23F2N3O3
MW 463.48

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

γ-Secretase Inhibitor DBZ

Description

Very potent and cell-permeable inhibitor of γ-secretase (GSI); potently inhibits Notch processing (IC50 values to be 1.7 nM in SupT1 cells)

Other popuplar synonyms for DBZ are: Dibenzazepine, γ-Secretase inhibitor XX and GSI-XX

J Milano et al. Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation. Toxicol. Sci. 2004, 82(1), 341-358.

TV Arumugam et al. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 2006, 12, 621-623.

T Aleksic and SM Feller. Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. Cell Communication and Signaling 2008, 6, 8.

List of publications using DBZ (Axon 1488) purchased from Axon Medchem

γ-Secretase inhibitor (GSI)

Chemical name

(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

Parent CAS No.

[209984-56-5]

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1 mg	€80.00	In Stock
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25 mg	€520.00	In Stock

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γ-Secretase Inhibitor DBZ - Deshydroxy LY411575 | YO-01027

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γ-Secretase Inhibitor DBZ - Deshydroxy LY411575 | YO-01027

Description

Chemical name

Parent CAS No.

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