Begacestat - GSI 953

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2117

CAS [769169-27-9]

MW 391.74

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO



Potent and selective γ-secretase inhibitor (γ-secratase inhibitor, GSI); Capable of reducing both Aβ40 and Aβ42 production in a cell line stably expressing human recombinant APP (EC50 values of 14.8 and 12.4 nM for Aβ40 and Aβ40 respectively). Begacestat was found to have >16-fold selectivity in vitro for the inhibition of APP processing over Notch
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5 mg €85.00 In Stock
25 mg €285.00 In Stock
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2 x 5 mg €130.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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