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DAPT

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1484

CAS [208255-80-5]

MF C23H26F2N2O4
MW 432.46

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

DAPT

Description

Inhibitor of γ-secretase.

*Promotion: DAPT is also part of Inhibitor Set(s):

Keywords: DAPT | supplier | γ-Secretase inhibitor | CAS [208255-80-5] | Amyloids | γ Secretase | Inhibitor | Enzymes

J Kanungo et al. The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins. J. Neurochem. 2008, 106, 2236-2248.

TQ Crawford, H Roelink. The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling. Dev Dyn. 2007, 236(3), 886-92.

TV Arumugam et al. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 2006, 12, 621-623.

CA Micchelli et al. γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003, 17, 79-81.

Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46 Stem Cell Differentiator

γ-Secretase inhibitor

Chemical name

(S)-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-propionylamino}-phenyl-acetic acid tert-butyl ester

Parent CAS No.

[208255-80-5]

Order

Size	Unit Price	Stock
5 mg	€90.00	In Stock
25 mg	€310.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€440.00	In Stock

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