RO 4929097

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2521

CAS [847925-91-1]

MF C22H20F5N3O3
MW 469.40

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO

RO 4929097


Potent γ-secretase inhibitor (GSI; IC50 value 4 nM) targeting Notch signaling with in vivo efficacy in various tumor cells, showing >100-fold selectivity with respect to 75 other proteins of various types (receptors, ion channels, and enzymes). Treatment of HEK293 cells with RO4929097 caused a dose-dependent decrease in the amount of Aβ peptides secreted into the culture medium (EC50 value 14 nM), and a strong dose-dependent inhibition of Notch processing in a Notch cell-based reporter assay (EC50 value 5 nM).

KEYWORDS: RO 4929097 | Supplier | γ-Secretase inhibitor | RO4929097 | CAS [847925-91-1] | Amyloids | γ Secretase | Inhibitor | GSI | Notch | signaling | Aβ peptides | tumor | melanoma | gamma Secretase

Size Unit Price Stock
5 mg €135.00 In Stock
25 mg €475.00 In Stock
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Size Unit Price Stock
2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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