γ Secretase

The γ-secretase enzyme (EC 3.4.23.46) is a multi-subunit enzyme complex that consists of four core components (presenilin, nicastrin, APH-1, and PEN-2). Presenilin is an aspartic protease and the catalytic component of the complex. γ-Secretase has the unusual ability to regulate intramembrane proteolysis (RIP) for a growing list of type 1 integral membrane proteins, including, APP, APP-like proteins (APLPs), E-Cadherin, ErbB4, ephrinB2, CD44, lipoprotein receptor-related protein (LRP), Notch, sterol regulatory element-binding protein (SREBP), interferon response element (IRE1), and activated transcription factor 6 (ATF-6)[1]. Especially for its capability to hydrolyze APP into amyloid-beta (Aβ) peptide whose abnormally folded fibrillar form is the primary component of amyloid plaques, γ-secretase  is a well-known pharmacological target in the field of Alzheimer’s disease[2].


[1] S. Krishnaswamy et al. The structure and function of Alzheimer’s gamma secretase enzyme complex. Crit. Rev. Clin. Lab. Sc. 2009, 46, 282-301.
[2] C. Kaether, C. Haass, H. Steiner. Assembly, trafficking and function of gamma-secretase. Neurodegener Dis. 2006, 3, 275-283.

7 Item(s)

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Axon ID Name Description From price
2117 Begacestat Selective γ-secretase inhibitor (GSI) €85.00
1487 BZ, γ-Secretase Inhibitor γ-Secretase inhibitor (GSI) €70.00
1484 DAPT γ-Secretase inhibitor €90.00
1488 DBZ, γ-Secretase Inhibitor γ-Secretase inhibitor (GSI) €65.00
2521 RO 4929097 Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells €135.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €240.00
5006 Stem Cell CSD inhibitor Set Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €155.00

7 Item(s)

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