The γ-secretase enzyme (EC 184.108.40.206) is a multi-subunit enzyme complex that consists of four core components (presenilin, nicastrin, APH-1, and PEN-2). Presenilin is an aspartic protease and the catalytic component of the complex. γ-Secretase has the unusual ability to regulate intramembrane proteolysis (RIP) for a growing list of type 1 integral membrane proteins, including, APP, APP-like proteins (APLPs), E-Cadherin, ErbB4, ephrinB2, CD44, lipoprotein receptor-related protein (LRP), Notch, sterol regulatory element-binding protein (SREBP), interferon response element (IRE1), and activated transcription factor 6 (ATF-6). Especially for its capability to hydrolyze APP into amyloid-beta (Aβ) peptide whose abnormally folded fibrillar form is the primary component of amyloid plaques, γ-secretase is a well-known pharmacological target in the field of Alzheimer’s disease.
 S. Krishnaswamy et al. The structure and function of Alzheimer’s gamma secretase enzyme complex. Crit. Rev. Clin. Lab. Sc. 2009, 46, 282-301.
 C. Kaether, C. Haass, H. Steiner. Assembly, trafficking and function of gamma-secretase. Neurodegener Dis. 2006, 3, 275-283.
|Axon ID||Name||Description||From price|
|2117||Begacestat||Selective γ-secretase inhibitor (GSI)||€85.00|
|1487||BZ, γ-Secretase Inhibitor||γ-Secretase inhibitor (GSI)||€70.00|
|1488||DBZ, γ-Secretase Inhibitor||γ-Secretase inhibitor (GSI)||€65.00|
|2521||RO 4929097||Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells||€135.00|
|5007||Stem Cell 5i inhibitor Set||Set of five inhibitors for neural differentiation of human pluripotent stem cells.||€240.00|
|5006||Stem Cell CSD inhibitor Set||Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp.||€155.00|