γ Secretase
The γ-secretase enzyme (EC 3.4.23.46) is a multi-subunit enzyme complex that consists of four core components (presenilin, nicastrin, APH-1, and PEN-2). Presenilin is an aspartic protease and the catalytic component of the complex. γ-Secretase has the unusual ability to regulate intramembrane proteolysis (RIP) for a growing list of type 1 integral membrane proteins, including, APP, APP-like proteins (APLPs), E-Cadherin, ErbB4, ephrinB2, CD44, lipoprotein receptor-related protein (LRP), Notch, sterol regulatory element-binding protein (SREBP), interferon response element (IRE1), and activated transcription factor 6 (ATF-6)[1]. Especially for its capability to hydrolyze APP into amyloid-beta (Aβ) peptide whose abnormally folded fibrillar form is the primary component of amyloid plaques, γ-secretase is a well-known pharmacological target in the field of Alzheimer’s disease[2].
[1] S. Krishnaswamy et al. The structure and function of Alzheimer’s gamma secretase enzyme complex. Crit. Rev. Clin. Lab. Sc. 2009, 46, 282-301.
[2] C. Kaether, C. Haass, H. Steiner. Assembly, trafficking and function of gamma-secretase. Neurodegener Dis. 2006, 3, 275-283.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2117 | Begacestat | Selective γ-secretase inhibitor (GSI) | €85.00 | |
| 1484 | DAPT | γ-Secretase inhibitor | €90.00 | |
| 2521 | RO 4929097 | Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells | €135.00 | |
| 5007 | Stem Cell 5i inhibitor Set | Set of five inhibitors for neural differentiation of human pluripotent stem cells. | €200.00 | |
| 5006 | Stem Cell CSD inhibitor Set | Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. | €140.00 | |
| 1487 | γ-Secretase Inhibitor BZ | γ-Secretase inhibitor (GSI) | €90.00 | |
| 1488 | γ-Secretase Inhibitor DBZ | γ-Secretase inhibitor (GSI) | €80.00 | |