Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2158

CAS [187389-53-3]

MF C11H18FNO5
MW 263.26

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

Boc-D-FMK

Description

Broad spectrum caspase inhibitor. Causes concentration-dependent inhibition of only TNFα-stimulated apoptosis (IC50 value 39 μM). Boc-D-FMK could significantly promote the survival of spinal motoneurons after root avulsion in neonates, but not in adult rats. Boc-D-FMK treatment reduces acute cell death after traumatic brain injury (TBI) by inhibiting mitochondrial release of cytochrome c, possibly via a mechanism involving initiator caspases-2, and -3-like, but not -8).

KEYWORS: Boc-D-FMK | supplier | Caspase inhibitor | apoptosis | TNF | boc-Aspartyl(OMe)-fluoromethylketone | BAF | traumatic | Brain injury | TBI | survival | motoneurons

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Size Unit Price Stock
2 mg €110.00 In Stock
5 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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