FLI 06

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2277

CAS [313967-18-9]

MF C25H30N2O5
MW 438.52

  • Purity: 100%
  • Soluble in DMSO

FLI 06


Notch signaling inhibitor (EC50 value 2.3 μM) that acts early in the secretory pathway. Although the precise molecular target of FLI 06 remains unclear, it effects a unique property to inhibit cargo recruitment to ER exit sites (ERESs) by changing its curvature. Consequently, it inhibits the membrane traffic of NotchΔE-eGFP at pre-ERES stages without fusion of ER-Golgi.FLI 06 does not inhibit the γ-secretase mediated proteolytical processing of NotchΔE-eGFP to NICD-eGFP at the plasma membrane.
Notch signaling inhibitor that acts early in the secretory pathway

Chemical name

cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Parent CAS No.


Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €285.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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