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Axon 3625
CAS [1496581-76-0]
MF C23H26F2N6OMW 440.49
GNE-3511 is a potent, selective, orally bioavailable and brain-penetrant DLK inhibitor with a Ki value of <0.0005 μM, giving an IC50 value of 0.030 μM for pJNK inhibition. GNE-3511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease.
KEYWORDS: GNE-3511 | Supplier | DLK inhibitor | GNE 3511 | GNE3511 | CAS [1496581-76-0] | MAPK (JNK) | Inhibitor | Enzymes | Alzheimer’s disease | Parkinson’s disease | MAP3K12
2-(6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-ylamino)isonicotinonitrile
[1496581-76-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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