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KPT-9274
- Soluble in DMSO and EtOH
- MF: C35H29F3N4O3
- MW: 610.62
Description
KPT-9274 is an orally bioavailable dual PAK4/NAMPT inhibitor with an IC50 value of 120 nM for NAMPT in a cell-free enzymatic assay. Interference with the PAK4 and NAD biosynthetic pathways results in reduction of G2/M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines.
More Information
| Parent CAS No. | 1643913-93-2 |
|---|---|
| Chemical Name | (E)-3-(6-Aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide |
| SMILES | C1(N)C=CC(/C=C/C(=O)NCC2OC3C(C4C=CC(F)=CC=4)=CC(C4C=CC(C(N5CCC(F)(F)CC5)=O)=CC=4)=CC=3C=2)=CN=1 |
| MFCD | MFCD28963903 |
| InChi | InChI=1S/C35H29F3N4O3/c36-28-9-7-24(8-10-28)30-19-26(23-3-5-25(6-4-23)34(44)42-15-13-35(37,38)14-16-42)17-27-18-29(45-33(27)30)21-41-32(43)12-2-22-1-11-31(39)40-20-22/h1-12,17-20H,13-16,21H2,(H2,39,40)(H,41,43)/b12-2+ |
| InChiKey | MRFOPLWJZULAQD-SWGQDTFXSA-N |
| CID | 117779453 |
| Short Description | PAK4/NAMPT inhibitor |
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