KPT-9274

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3557

CAS [1643913-93-2]

MF C35H29F3N4O3
MW 610.62

  • Purity: 98%
  • Soluble in DMSO and EtOH
Recently added

KPT-9274

Description

KPT-9274 is an orally bioavailable dual PAK4/NAMPT inhibitor with an IC50 value of 120 nM for NAMPT in a cell-free enzymatic assay. Interference with the PAK4 and NAD biosynthetic pathways results in reduction of G2/M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines.

KEYWORDS: KPT-9274 | Supplier | PAK4/NAMPT inhibitor | KPT9274 | KPT 9274 | CAS [1643913-93-2] | Non Selective (Phosphorylation Substrates) | PAK | Inhibitor | Enzymes | Kidney cancer | Renal cell carcinoma | RCC | Lymphoma

Orally bioavailable dual PAK4/NAMPT inhibitor

Chemical name

(E)-3-(6-Aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide

Parent CAS No.

[1643913-93-2]

Order
Size Unit Price Stock
5 mg €130.00 In Stock
25 mg €460.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...