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Axon 3557

CAS [1643913-93-2]

MF C35H29F3N4O3
MW 610.62

  • Purity: 98%
  • Soluble in DMSO and EtOH



KPT-9274 is an orally bioavailable dual PAK4/NAMPT inhibitor with an IC50 value of 120 nM for NAMPT in a cell-free enzymatic assay. Interference with the PAK4 and NAD biosynthetic pathways results in reduction of G2/M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines.

KEYWORDS: KPT-9274 | Supplier | PAK4/NAMPT inhibitor | KPT9274 | KPT 9274 | CAS [1643913-93-2] | Non Selective (Phosphorylation Substrates) | PAK | Inhibitor | Enzymes | Kidney cancer | Renal cell carcinoma | RCC | Lymphoma

Orally bioavailable dual PAK4/NAMPT inhibitor

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €130.00 In Stock
25 mg €460.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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