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Axon 3557
CAS [1643913-93-2]
MF C35H29F3N4O3MW 610.62
KPT-9274 is an orally bioavailable dual PAK4/NAMPT inhibitor with an IC50 value of 120 nM for NAMPT in a cell-free enzymatic assay. Interference with the PAK4 and NAD biosynthetic pathways results in reduction of G2/M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines.
KEYWORDS: KPT-9274 | Supplier | PAK4/NAMPT inhibitor | KPT9274 | KPT 9274 | CAS [1643913-93-2] | Non Selective (Phosphorylation Substrates) | PAK | Inhibitor | Enzymes | Kidney cancer | Renal cell carcinoma | RCC | Lymphoma
(E)-3-(6-Aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide
[1643913-93-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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