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Axon 3552
CAS [1432597-26-6]
MF C25H22N6MW 406.48
Potent ALK2-biased BMP type I receptor kinase inhibitor (IC50 values 2.4 nM, 1.3 nM, and 85.8 nM for ALK1, 2, and 3 resp.), showing nearly 4 orders of selectivity for BMP versus the closely related TGF-β and Activin type I receptors. Closely related to LDN 193189 (Axon 1509). Note: Trihydrochloride salt form of LDN 212854 (Axon 2201) is also available.
KEYWORDS: LDN 212854 | Supplier | BMP inhibitor | LDN212854 | LDN-212854 | CAS [1432597-26-6] | [2109414-80-2] | TGF-β | BMP-ALK | ALK | type I | dorsomorphin | ALK2 | ALK-2 | ALK1 | ALK3 | bone morphogenetic protein | Antagonist | Receptors
5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
[1432597-26-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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