SC-514

Based on 88 reference(s) in Google Scholar 8 10 88

Axon 3536

CAS [354812-17-2]

MF C9H8N2OS2
MW 224.30

  • Purity: 99%
  • Soluble in DMSO
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SC-514

Description

SC-514 is a potent, selective, reversible and ATP-competitive IKK-2 inhibitor with IC50 values of 3-12 μM. SC-514 inhibits the native IKK complex or recombinant human IKK-1/IKK-2 heterodimer and IKK-2 homodimer similarly. Moreover, SC-514 inhibits transcription of NF-κB-dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent manner.

KEYWORDS: SC-514 | Supplier | IKK-2 inhibitor | SC514 | SC 514 | CAS [354812-17-2] | IκB | IKK | Inhibitor | Enzymes | Rheumatoid arthritis

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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