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Axon 3536
CAS [354812-17-2]
MF C9H8N2OS2MW 224.30
SC-514 is a potent, selective, reversible and ATP-competitive IKK-2 inhibitor with IC50 values of 3-12 μM. SC-514 inhibits the native IKK complex or recombinant human IKK-1/IKK-2 heterodimer and IKK-2 homodimer similarly. Moreover, SC-514 inhibits transcription of NF-κB-dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent manner.
KEYWORDS: SC-514 | Supplier | IKK-2 inhibitor | SC514 | SC 514 | CAS [354812-17-2] | IκB | IKK | Inhibitor | Enzymes | Rheumatoid arthritis
4-Amino-2,3'-bithiophene-5-carboxamide
[354812-17-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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