GW4869 trifluoroacetate - GW554869 TFA

Based on 219 reference(s) in Google Scholar 8 10 219

Axon 3289

CAS [475570-61-7 (parent)]

MF C30H28N6O2.2C2HF3O2
MW 732.63

  • Purity: 97%
  • Soluble in DMSO
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GW4869 trifluoroacetate

Description

GW4869 is a noncompetitive inhibitor of neutral, magnesium-dependent sphingomyelinase (N-SMase) with an IC50 value of 1 μM. GW4869 did not inhibit acid SMase at up to at least 150 μM.

*GW4869 is poorly soluble in DMSO and other common solvents. GW4869 is usually formulated as a suspension. GW4869 (TFA) has a better solubility and bioavailability than GW4869 (HCl).

KEYWORDS: GW4869 trifluoroacetate | supplier | N-SMase inhibitor | GW554869 TFA | GW 4869 | GW 554869 | GW-4869 | GW-554869 | CAS [475570-61-7] | Sphingolipid | PDE | Inhibitor | Enzymes | TNF

Noncompetitive, neutral, magnesium-dependent SMase inhibitor

Chemical name

3-[4-[3-[4-(4,5-Dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide trifluoroacetate

Parent CAS No.

[475570-61-7]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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