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Tenofovir
- PMPA
- Optical Purity: Optically pure
- Soluble in water and 0.1N NaOH(aq)
- MF: C9H14N5O4P
- MW: 287.21
Description
Tenofovir is a selective inhibitor of HIV-1 reverse transcriptase. Tenofovir alafenamide (Axon 3302) is also available as an orally bioavailable, intracellular prodrug of Tenofovir.
More Information
| Parent CAS No. | 147127-20-6 |
|---|---|
| Chemical Name | (R)-(1-(6-Amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid |
| SMILES | N1=C(N)C2N=CN(C[C@@H](C)OCP(O)(O)=O)C=2N=C1 |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1 |
| InChiKey | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
| CID | 464205 |
| Short Description | HIV-1 RT inhibitor |
References
- RA Heijtink et al. Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. Antimicrobial Agents and Chemotherapy Sep 1994, 38 (9) 2180-2182.
- Z Suo et al. Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine. J Biol Chem. 1998 Oct 16;273(42):27250-8.
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