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BPN14770
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H15ClF3NO2
- MW: 405.8
Description
BPN14770 is a potent, selective, allosteric inhibitor of PDE4D with an IC50 value of 7.8 nM (PDE4D7-S129D). BPN14770 showed increased potency in humanized PDE4D mice as compared to wild-type mice. Moreover, BPN14770 increased brain cAMP, increased phosphorylation of CREB, augmented the late phase of hippocampal long-term potentiation (LTP), improved short and long-term memory, and increased production of brain-derived neurotrophic factor (BDNF) in hippocampus.
More Information
| Parent CAS No. | 1606974-33-7 |
|---|---|
| Chemical Name | 2-(4-((2-(3-Chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetic acid |
| SMILES | C1(C(F)(F)F)C=C(CC2C=CC(CC(=O)O)=CC=2)C=C(C2C=C(Cl)C=CC=2)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28) |
| InChiKey | LTSUMTMGJHPGFX-UHFFFAOYSA-N |
| CID | 90111638 |
| Short Description | PDE4D inhibitor |
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