BPN14770

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3148

CAS [1606974-33-7]

MF C21H15ClF3NO2
MW 405.80

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO
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BPN14770

Description

BPN14770 is a potent, selective, allosteric inhibitor of PDE4D with an IC50 value of 7.8 nM (PDE4D7-S129D). BPN14770 showed increased potency in humanized PDE4D mice as compared to wild-type mice. Moreover, BPN14770 increased brain cAMP, increased phosphorylation of CREB, augmented the late phase of hippocampal long-term potentiation (LTP), improved short and long-term memory, and increased production of brain-derived neurotrophic factor (BDNF) in hippocampus.

KEYWORDS: BPN14770 | supplier | PDE4D inhibitor | BPN 14770 | BPN-14770 | CAS [1606974-33-7] | cAMP | PDE | Inhibitor | Enzymes | Fragile X Syndrome

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Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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