BPN14770 is a potent, selective, allosteric inhibitor of PDE4D with an IC50 value of 7.8 nM (PDE4D7-S129D). BPN14770 showed increased potency in humanized PDE4D mice as compared to wild-type mice. Moreover, BPN14770 increased brain cAMP, increased phosphorylation of CREB, augmented the late phase of hippocampal long-term potentiation (LTP), improved short and long-term memory, and increased production of brain-derived neurotrophic factor (BDNF) in hippocampus.

KEYWORDS: BPN14770 | supplier | PDE4D inhibitor | BPN 14770 | BPN-14770 | CAS [1606974-33-7] | cAMP | PDE | Inhibitor | Enzymes | Fragile X Syndrome