WX-132-18B is a microtubule-depolymerizing agent that selectively acts on the colchicine-binding site of tubulin and exerts potent in vitro and in vivo anti-tumor effects. Specifically, WX-132-18B exhibited high in vitro cytotoxic activity (GI50 value of 1.9–3.2 nM), significant potency against tubulin assembly (IC50 value of 0.77 μM), and substantial inhibition of colchicine binding (99% at 5 μM). Moreover, WX-132-18B caused cell arrest in G2/M phase.

KEYWORDS: WX-132-18B | Supplier | Microtubule inhibitor | WX132-18B | WX 132-18B | CAS [1415262-07-5] | Cytoskeleton | Tubulin | Inhibitor | Proteins | Colchicine | G2/M phase