AR7 - Atypical retinoid 7

Based on 4 reference(s) in Google Scholar 9 10 4

Axon 2679

CAS [80306-38-3]

MW 257.71

  • Purity: 99,7%
  • Soluble in DMSO



Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).

KEYWORDS: AR7 |  supplier | RARα antagonist | Atypical retinoid 7  | AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative

Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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