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HIF-2a Translation Inhibitor 76
- Soluble in DMSO
- MF: C9H9N3O4S2
- MW: 287.32
Description
HIF-2a translation inhibitor (IC50 value 5 µM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
More Information
| Parent CAS No. | 882268-69-1 |
|---|---|
| Chemical Name | Methyl 3-(2-(cyano(methylsulfonyl)methylene)hydrazinyl)thiophene-2-carboxylate |
| SMILES | C1(C(OC)=O)SC=CC=1N/N=C(/C#N)S(C)(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C9H9N3O4S2/c1-16-9(13)8-6(3-4-17-8)11-12-7(5-10)18(2,14)15/h3-4,11H,1-2H3/b12-7- |
| InChiKey | OOGAPDPPVHJYGJ-GHXNOFRVSA-N |
| CID | 5715626 |
| Short Description | HIF-2a translation inhibitor |
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