GlyH 101

Based on 171 reference(s) in Google Scholar 10 10 171

Axon 2572

CAS [328541-79-3]

MF C19H15Br2N3O3
MW 493.15

  • Purity: 98%
  • Soluble in DMSO

GlyH 101


Highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitor (Ki value 4.3 µM in CFTR-expressing FRT cells) targeting mitochondrial functions, independently of chloride channel inhibition. GlyH 101 induces a rapid increase in ROS levels and depolarizes mitochondria in the four cell types, suggesting that these effects are independent of CFTR inhibition. Moreover, intraluminal GlyH 101 (2.5 g) reduced by 80% cholera toxin-induced intestinal fluid secretion in a closed-loop model of cholera.

KEYWORDS: GlyH 101 | supplier | CFTR inhibitor | GlyH101 | CAS [328541-79-3] | Chloride | CFTR | Inhibitor | Ion Channels | cystic fobrosis | cholera | diarrhea | inward rectifying | current | ROS | conductance | mitochondrial

Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €420.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...