YK 4-279

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2469

CAS [1037184-44-3]

MF C17H13Cl2NO4
MW 366.20

  • Purity: 99%
  • Soluble in DMSO

YK 4-279


Inhibitor of interactions between the fusion protein EWS-FLI1 and RNA helicase A (RHA; Kd value 9.48 µM) with a detrimental effect on ESFT cells both in vitro and in vivo. YK-4-279 is also found to potently inhibit biological activity of ERG (Kd value 11.7 µM) and ETV1 (Kd value 17.4 µM) resulting in suppression of both primary tumor growth and metastasis of fusion positive prostate cancer xenografts. ETV1 is a member of the translocated erythroblastosis virus E26 transforming sequence (ETS) family of transcription factors) and targets MMP7, MMP13, FKBP10 and GLYATL2 genes, among several others.
Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €345.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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