Mirabegron - YM 178 | Betanis

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2414

CAS [223673-61-8]

MF C21H24N4O2S
MW 396.51

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Mirabegron

Description

Highly selective and orally active agonist of the human β3-adrenoceptor (EC50 value 22.4 nM) with >440 fold selectivity over β1, and β2. FDA approved therapeutic drug for the treatment of symptoms of overactive bladder such as urinary frequency, urgency, and urge incontinence. YM178 (Mirabegron) does not affect the amplitude of rhythmic bladder contractions at doses at which it reduces contraction frequency.

T. Takasu et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function. J Pharmacol Exp Ther. 2007 May;321(2):642-7.

E. Sacco et al. Mirabegron: a review of recent data and its prospects in the management of overactive bladder. Ther Adv Urol. 2012 Dec;4(6):315-24.

N. Aizawa et al. Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin. Eur Urol. 2012 Dec;62(6):1165-73.

Highly selective and orally active agonist of the human β3-adrenoceptor

Chemical name

(R)-2-(2-aminothiazol-4-yl)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)acetamide

Parent CAS No.

[223673-61-8]

Order

Size	Unit Price	Stock
10 mg	€120.00	In Stock
50 mg	€450.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1138	Mirtazapine	5-HT antidepressant	€65.00
1154	B-HT 933 dihydrochloride	α2 adrenoceptor agonist	€120.00
1155	Efaroxan hydrochloride	α2 adrenoceptor antagonist	€65.00
1157	Bromobuterol	β2 agonist	€85.00
1159	Celiprolol hydrochloride	β1 antagonist	€135.00
1269	SSR 69071	HLE inhibitor	€150.00
1290	ST 91	α2 adrenoceptor agonist	€80.00
1371	Atipamezole hydrochloride	α2 adrenoceptor antagonist	€95.00
1518	Timolol maleate	β1 adrenergic antagonist	€80.00
1555	Brimonidine tartrate	α2 adrenoceptor agonist	€70.00
1750	MIBG hemisulfate	Radiopharmaceutical; Noradrenaline analogue	€120.00
2040	Prazosin hydrochloride	Peripherally acting α1 adrenoceptor antagonist	€50.00
2329	NS 19504	Potent activator of large-conductance Ca2+-activated potassium (BK) channels	€90.00
1519	Sunepitron hydrochloride	Anxiolytic and antidepressant drug	€140.00
3488	(±)-CGP-12177A	β1/β2 adrenoceptor antagonist, β3 adrenoceptor agonist	€120.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

Mirabegron - YM 178 | Betanis

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Mirabegron - YM 178 | Betanis

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us