Kartogenin - KGN

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2378

CAS [4727-31-5]

MF C20H15NO3
MW 317.34

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO



Small molecule promoting robust chondrocyte differentiation from primary human mesenchymal stem cells (MSCs; EC50 value 100 nM). Kartogenin (KGN) treatment of bone marrow stromal cells (BMSCs) induced the expresion of both Col. II and aggrecan in a dose-dependent manner, and upregulates Sox-9 gene expression. KGN does not alter either MMP-3, MMP-13, or aggrecanase expression in primary chondrocytes and MSCs.
KGN may be used to enhance tendon/bone interface healing through the direct, local delivery of KGN injections into the gap between the tendon graft and the bone surface during ACL reconstruction.

Size Unit Price Stock
10 mg €75.00 In Stock
50 mg €225.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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