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SR 3576

Axon 2365
CAS:  1164153-22-3
Purity:  99%
  • Soluble in DMSO
  • MF:  C27H27N5O5
  • MW:  501.53

Description

SR 3576 is a very potent JNK3 inhibitor with an IC50 value of 7 nM and greater than 2800-fold selectivity over p38. It shows cell-based potency around 1 μM and is useful for studying JNK3-selective MAPK pharmacology.

JNK3 is enriched in neuronal tissues and is implicated in stress signaling, neuronal injury and neurodegenerative disease mechanisms. SR 3576 supports subtype-selective investigation of JNK3 compared with other MAPK family members.

Key Features

  • Potent JNK3 inhibitor
  • IC50: 7 nM
  • >2800-fold selectivity over p38
  • Cell-based potency around 1 μM

Applications

  • JNK3 kinase pharmacology
  • MAPK selectivity profiling
  • Neuronal stress-signaling assays
  • Neurodegeneration pathway research

More Information

Parent CAS No. 1164153-22-3
Chemical Name 3-(4-(3-m-tolylureido)-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
SMILES C(NC1=CC(OC)=C(OC)C(OC)=C1)(=O)C1=CC=CC(N2C=C(NC(NC3=CC=CC(C)=C3)=O)C=N2)=C1
MFCD MFCD18632556
InChi InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
InChiKey MTFAYLZZDJGFGV-UHFFFAOYSA-N
CID 70702008
Short Description JNK3 inhibitor

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