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JNK-IN-8
- JNK Inhibitor XVI
Axon 2361
CAS:
1410880-22-6
Purity:
98%
- Soluble in DMSO
- MF: C29H29N7O2
- MW: 507.59
Description
JNK-IN-8 is a potent, selective covalent JNK inhibitor with IC50 values of 4.67 nM, 18.7 nM and 0.98 nM for JNK1, JNK2 and JNK3, respectively. It inhibits c-Jun phosphorylation in cells through covalent modification of a conserved cysteine residue in JNK.
JNK signaling regulates stress responses, inflammation, apoptosis and transcriptional activation through substrates such as c-Jun. JNK-IN-8 is a high-value probe for studying JNK-dependent MAPK signaling in cancer, neurodegeneration and immune models.
Key Features
- Potent and covalent JNK inhibitor
- IC50s: 0.98 nM at JNK3, 4.67 for JNK1 and 18.7 nM for JNK2
- Blocks cellular c-Jun phosphorylation
- Mechanism depends on conserved cysteine modification
Applications
- JNK/MAPK pathway research
- c-Jun phosphorylation assays
- Stress-response and apoptosis studies
- Cancer, neurodegeneration and autoimmune disease models
More Information
| Parent CAS No. | 1410880-22-6 |
|---|---|
| Chemical Name | 3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide |
| SMILES | C1(NC(=O)/C=C/CN(C)C)C=C(C(NC2C=CC(NC3N=C(C4C=CC=NC=4)C=CN=3)=C(C)C=2)=O)C=CC=1 |
| MFCD | MFCD22124890 |
| InChi | InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ |
| InChiKey | GJFCSAPFHAXMSF-UXBLZVDNSA-N |
| CID | 57340686 |
| Short Description | JNK inhibitor |
JNK-IN-8
covalent JNK inhibitor
covalent JNK
MAPK
JNK1
JNK2
JNK3
Inhibitor
MAPK/ERK signaling
JNK/MAPK pathway research
c-Jun phosphorylation assays
Stress-response and apoptosis studies
Cancer and neurodegeneration and autoimmune disease models
apoptosis
inflammation
neurodegeneration
cancer biology
receptor selectivity
signal transduction
transcriptional regulation
CAS 1644498-56-5
CAS 1410880-22-6
Axon Medchem
Axon 2361
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