TM 5275

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2344

CAS [1103926-82-4]

MF C28H27ClN3NaO5
MW 543.97

  • Purity: 99%
  • Soluble in DMSO

TM 5275


Selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 µM in tissue plasminogen activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and nonhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition.
Additionally, TM 5275 represents a novel class of anti-inflammatory agents targeting macrophage migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor–related protein (IC50 values 3.13 µM and 3.02 µM for LRP1 protein Cl II and Cl IV, respectively).

Size Unit Price Stock
5 mg €105.00 In Stock
25 mg €365.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €150.00 In Stock
2 x 25 mg €580.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...