FRAX 486

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2331

CAS [1232030-35-1]

MF C25H23Cl2FN6O
MW 513.39

  • Purity: 99%
  • Soluble in DMSO

FRAX 486

Description

Bioavailable and brain penetrating inhibitor of group I p21-activated kinases (IC50 values 8.25 nM, 39.5 nM, and 55.3 nM for PAK1, PAK2, and PAK3, respectively) with good selectivity over PAK4 (IC50 value 779 nM) FRAX486 rescues the dendritic spine abnormality and audiogenic seizures, and reduces autism-like phenotypes of hyperactivity and restrictive or repetitive behaviors in Fmr1 KO mice. Not only represents FRAX-486 a potential breakthrough in the research for a treatment of Fragile X syndrome (FXS), it was also found to ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.
Order
Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €335.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €150.00 In Stock
2 x 25 mg €540.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...