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STF 118804
Axon 2253
CAS:
894187-61-2
Purity:
98%
- Soluble in DMSO
- MF: C25H23N3O4S
- MW: 461.53
Description
Highly specific, next-generation NAMPT inhibitor, that reduces the viability of most B-ALL cell lines with high potency demonstrating IC50 values in the low nanomolar range, and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. Additionally, STF 118804 induces leukemia cell apoptosis without antecedent cell cycle arrest, and targets leukemia stem cells.
More Information
| Parent CAS No. | 894187-61-2 |
|---|---|
| Chemical Name | 4-(5-Methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide |
| SMILES | C(NCC1=CC=CN=C1)(=O)C1=CC=C(C2=NC(CS(C3=CC=C(C)C=C3)(=O)=O)=C(C)O2)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29) |
| InChiKey | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
| CID | 20916937 |
| Short Description | NAMPT inhibitor |
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