TEPP 46 - ML 265

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2240

CAS [1221186-53-3]

MF C17H16N4O2S2
MW 372.46

  • Purity: 99%
  • Soluble in DMSO



Potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Continuous dosing of mice with TEPP 46 decreased the development of human cancer cell xenografts, suggesting that increased pyruvate kinase activity can impair tumorigenesis.TEPP 46 can mimic the enzymatic properties of PKM1 in PKM2-expressing cells, alter cell metabolism, and induces changes in the kinetic properties of PKM2 that are identical to those induced by the endogenous PKM2 activator FBP.

KEYWORDS:  TEPP 46 | supplier | PKM2 activator  | ML 265 | TEPP46 | ML265 | TEPP-46 | ML-265 | CAS [1221186-53-3] | Pyyruvate | PKM2 | Activator | Enzymes |  Glycolysis | Warburg | tumorigenesis | cancer | glucose metabolism

Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €300.00 In Stock
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Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €480.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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