TEPP-46 - ML265

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2240

CAS [1221186-53-3]

MF C17H16N4O2S2
MW 372.46

  • Purity: 99%
  • Soluble in DMSO



Potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Continuous dosing of mice with TEPP-46 decreased the development of human cancer cell xenografts, suggesting that increased pyruvate kinase activity can impair tumorigenesis.TEPP-46 can mimic the enzymatic properties of PKM1 in PKM2-expressing cells, alter cell metabolism, and induces changes in the kinetic properties of PKM2 that are identical to those induced by the endogenous PKM2 activator FBP.

KEYWORDS: TEPP-46 | Supplier | PKM2 activator | ML265 | TEPP46 | ML 265 | TEPP 46 | ML-265 | CAS [1221186-53-3] | Pyruvate | PKM2 | Activator | Enzymes |  Glycolysis | Warburg | tumorigenesis | cancer | glucose metabolism

Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €290.00 In Stock
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Size Unit Price Stock
2 x 5 mg €130.00 In Stock
2 x 25 mg €440.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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