Gisadenafil besylate - UK 369003 | PF 01224715

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2218

CAS [334827-98-4]

MF C22H31N7O5S.C7H8O3S
MW 677.79

Purity: 99%
Soluble in water and DMSO

Gisadenafil besylate

Description

Potent and selective inhibitor of cGMP-specific PDE5 (IC50 value 1.23 nM) with improved selectivity over PDE6 (PDE5/6 selectivity value 117 and >3000-fold selectivity over other PDEs). Gisadenafil has the potential for oral bioavailability and dose-proportional pharmacokinetics.

Close analogue of Sildenafil (Viagra; Axon 2046)

D.J. Rawson et al. The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg. Med. Chem. 2012, 20, 498-509.

N.A.M. Tamimi et al. A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated (...). BJU Int. 2010, 106, 674–680.

Potent and selective inhibitor of PDE5

Chemical name

5-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl)-3-ethyl-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one benzenesulfonate

Parent CAS No.

[334826-98-1]

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Gisadenafil besylate - UK 369003 | PF 01224715

Description

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Parent CAS No.

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Gisadenafil besylate - UK 369003 | PF 01224715

Description

Chemical name

Parent CAS No.

Related Products

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