SRPIN 340

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2200

CAS [218156-96-8]

MF C18H18F3N3O
MW 349.35

Purity: 99%
Soluble in DMSO

SRPIN 340

Description

Selective ATP-competitive inhibitor of SRPK kinase activity (Ki 0.89 μM for SRPK1; 99.2% inhibition of RS-repeat peptide substrate phosphorylation at 10μM). SRPIN340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs) significantly, including Clk1 and Clk4 and >140 other SR kinases. SRPIN 340 promotes SRp75 degradation, and dose dependently suppressed HCV 1b and 2a replication (EC50 values of 4.7 μM and 15.8 μM resp.) and propagation of Sindbis and HCV-JFH1 viruses in cell culture.

Y. Karakama et al. Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase. Antimicrob. Agents Chemother. 2010, 54, 3179-3186.

T. Fukuhara et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. PNAS USA. 2006, 103, 11329-11333.

S. Oltean et al. SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem. Soc. Trans. 2012, 40, 831–835.

Angiogenesis Cell Signaling & Oncology Immunology SRPK PI3K-Akt-mTOR EC 2.7.11.1 Antiviral agents Infectious Disease

Selective ATP-competitive inhibitor of SRPK kinase activity

Chemical name

N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide

Parent CAS No.

[218156-96-8]

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10 mg	€95.00	In Stock
50 mg	€335.00	In Stock

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